Johne's Disease (pronounced YO-knees), or paratuberculosis, is a chronic wasting disease that causes considerable production losses in adult cattle, sheep, goats, deer, llamas, elk, and bison, and other ruminants. The disease is caused by Mycobacterium paratuberculosis, a bacterium related to tuberculosis.

Johne's disease typically starts as an infection in calves, though visible signs do not generally appear until cattle are 2 to 5 years of age (and sometimes much older).  The infection is difficult to detect in its early stages.  This bacterium causes an inflamed intestinal tract that results in severe weight loss and diarrhea and lower milk production.  Infected cattle frequently eat well, and look bright, however, they appear to be unthrifty.  Body temperature may or may not be elevated.  There is no cure for Johne's disease once an animal becomes infected. 

Eradication of Johne's disease is extremely difficult because of its insidious nature, long incubation period, difficulty in early detection, and major management changes necessary to prevent and eradicate it.   Consultation and action by a veterinarian experienced in the management of Johne's disease is necessary for the development of a herd-control and eradication program.

Johne's disease has been reported in almost all countries around the world.

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Information contained in this article from one or more of the following:
Alabama Cooperative Extension System
South Carolina Extension Service
Nebraska Extension Service
Oklahoma State Cooperative Extension Service
University of Nebraska Cooperative Extension
University of Minnesota Extension Service